Mitochondrial variation affects disease risk

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Is mitochondrial DNA variation associated with sporadic breast cancer risk?

In the May 15, 2007 issue of Cancer Research , Bai et al. (1) claimed that individuals carrying haplogroup K mitochondrial DNA (mtDNA) lineages are at significantly increased risk of developing breast cancer, whereas those bearing haplogroup U lineages have a significantly decreased risk. However, this study has a number of drawbacks. First, haplogroup K is phylogenetically nested within haplog...

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Authors’ response: Understanding variation in disease risk

that neither the exact nor the approximate solution describes cancer incidence data well, and that models incorporating cell proliferation kinetics do better. 4 Be that as it may, for any stochastic model, stochastic heterogeneity is immediately introduced if the stochastic solution is used. Inter-individual variations in susceptibility arising from variations in the rates of critical biologica...

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ژورنال

عنوان ژورنال: Nature Reviews Genetics

سال: 2014

ISSN: 1471-0056,1471-0064

DOI: 10.1038/nrg3760