Mitochondrial variation affects disease risk
نویسندگان
چکیده
منابع مشابه
Is mitochondrial DNA variation associated with sporadic breast cancer risk?
In the May 15, 2007 issue of Cancer Research , Bai et al. (1) claimed that individuals carrying haplogroup K mitochondrial DNA (mtDNA) lineages are at significantly increased risk of developing breast cancer, whereas those bearing haplogroup U lineages have a significantly decreased risk. However, this study has a number of drawbacks. First, haplogroup K is phylogenetically nested within haplog...
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Although the mitochondrial genome exhibits high mutation rates, common mitochondrial DNA (mtDNA) variation has not been consistently associated with pancreatic cancer. Here, we comprehensively examined mitochondrial genomic variation by sequencing the mtDNA of participants (cases = 286, controls = 283) in a San Francisco Bay Area pancreatic cancer case-control study. Five common variants were a...
متن کاملMitochondrial Genetic Variation in Iranian Infertile Men with Varicocele
Objective Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observe...
متن کاملAuthors’ response: Understanding variation in disease risk
that neither the exact nor the approximate solution describes cancer incidence data well, and that models incorporating cell proliferation kinetics do better. 4 Be that as it may, for any stochastic model, stochastic heterogeneity is immediately introduced if the stochastic solution is used. Inter-individual variations in susceptibility arising from variations in the rates of critical biologica...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2014
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3760